CD44 Promotes Migration and Invasion of Docetaxel-Resistant Prostate Cancer Cells Likely via Induction of Hippo-Yap Signaling

CD44 Promotes Migration and Invasion of Docetaxel-Resistant Prostate Cancer Cells Likely via Induction of Hippo-Yap Signaling

Patients receiving docetaxel developed a drug resistance within a few months. We generated docetaxel-resistant PC/DX25 and DU/DX50 CRPC cells from PC-3 and DU-145 PCa cells, respectively. We investigated the mechanism behind why PC/DX25 and DU/DX50 cells exhibited higher migration and invasion abili...

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Bibliographic Details
Main Authors:	Chih-Jen Lai, Ching-Yu Lin, Wen-Ying Liao, Tzyh-Chyuan Hour, Horng-Dar Wang, Chih-Pin Chuu
Format:	Article
Language:	English
Published:	MDPI AG 2019-03-01
Series:	Cells
Subjects:	prostate cancer CD44 YAP docetaxel-resistant migration invasion PC-3 DU-145
Online Access:	https://www.mdpi.com/2073-4409/8/4/295

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