The macrophage infectivity potentiator of Trypanosoma cruzi induces innate IFN-γ and TNF-α production by human neonatal and adult blood cells through TLR2/1 and TLR4

The macrophage infectivity potentiator of Trypanosoma cruzi induces innate IFN-γ and TNF-α production by human neonatal and adult blood cells through TLR2/1 and TLR4

We previously identified the recombinant (r) macrophage (M) infectivity (I) potentiator (P) of the protozoan parasite Trypanosoma cruzi (Tc) (rTcMIP) as an immuno-stimulatory protein that induces the release of IFN-γ, CCL2 and CCL3 by human cord blood cells. These cytokines and chemokines are import...

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Bibliographic Details
Main Authors: Sarra Ait Djebbara, Saria Mcheik, Pauline Percier, Noria Segueni, Antoine Poncelet, Carine Truyens
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
IFN-γ
TNF-α
TLR2
TLR4
adjuvant
neonatal immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1180900/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1180900/full

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