Nuclear Magnetic Resonance Approaches in the Study of 2-Oxo Acid Dehydrogenase Multienzyme Complexes—A Literature Review

Nuclear Magnetic Resonance Approaches in the Study of 2-Oxo Acid Dehydrogenase Multienzyme Complexes—A Literature Review

The 2-oxoacid dehydrogenase complexes (ODHc) consist of multiple copies of three enzyme components: E1, a 2-oxoacid decarboxylase; E2, dihydrolipoyl acyl-transferase; and E3, dihydrolipoyl dehydrogenase, that together catalyze the oxidative decarboxylation of 2-oxoacids, in the presence of thiamin d...

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Bibliographic Details
Main Authors: Mulchand S. Patel, Sowmini Kumaran, Frank Jordan
Format: Article
Language:English
Published: MDPI AG 2013-09-01
Series:Molecules
Subjects:
2-oxoacid dehydrogenase complex
pyruvate dehydrogenase complex
thiamin diphosphate
protein-protein interaction
substrate channeling
lipoyl domain
peripheral subunit binding domain
NMR
Online Access:http://www.mdpi.com/1420-3049/18/10/11873

Internet

http://www.mdpi.com/1420-3049/18/10/11873

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