Antifibrotic effects of curcumin are associated with overexpression of cathepsins K and L in bleomycin treated mice and human fibroblasts

Antifibrotic effects of curcumin are associated with overexpression of cathepsins K and L in bleomycin treated mice and human fibroblasts

<p>Abstract</p> <p>Background</p> <p>Lung fibrosis is characterized by fibroblast proliferation and the deposition of collagens. Curcumin, a polyphenol antioxidant from the spice tumeric, has been shown to effectively counteract fibroblast proliferation and reducing inf...

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Bibliographic Details
Main Authors: Zhang Dongwei, Huang Chuangfang, Yang Changfu, Liu Renzuo J, Wang Jifeng, Niu Jianzhao, Brömme Dieter
Format: Article
Language:English
Published: BMC 2011-11-01
Series:Respiratory Research
Subjects:
lung fibrosis
curcumin
cathepsins
collagen
TGF-β1
apoptosis
protease inhibitors.
Online Access:http://respiratory-research.com/content/12/1/154

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http://respiratory-research.com/content/12/1/154

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