Genetic deletion of the 67‐kDa isoform of glutamate decarboxylase alters conditioned fear behavior in rats

Genetic deletion of the 67‐kDa isoform of glutamate decarboxylase alters conditioned fear behavior in rats

The GABAergic system is thought to play an important role in the control of cognition and emotion, such as fear, and is related to the pathophysiology of psychiatric disorders. For example, the expression of the 67‐kDa isoform of glutamate decarboxylase (GAD67), a GABA‐producing enzyme, is downregul...

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Bibliographic Details
Main Authors: Kazuyuki Fujihara, Takumi Sato, Yoshiki Miyasaka, Tomoji Mashimo, Yuchio Yanagawa
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:FEBS Open Bio
Subjects:
amygdala
CRISPR/Cas9
fear conditioning
GABA
genome editing
inhibitory neurotransmitter
Online Access:https://doi.org/10.1002/2211-5463.13065

Internet

https://doi.org/10.1002/2211-5463.13065

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