OGG1 Inhibition Reduces Acinar Cell Injury in a Mouse Model of Acute Pancreatitis

OGG1 Inhibition Reduces Acinar Cell Injury in a Mouse Model of Acute Pancreatitis

Acute pancreatitis (AP) is a potentially life-threatening gastrointestinal disease with a complex pathology including oxidative stress. Oxidative stress triggers oxidative DNA lesions such as formation of 7,8-dihydro-8-oxo-2′-oxoguanine (8-oxoG) and also causes DNA strand breaks. DNA breaks can acti...

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Bibliographic Details
Main Authors: Zoltán Hajnády, Máté Nagy-Pénzes, Máté A. Demény, Katalin Kovács, Tarek El-Hamoly, József Maléth, Péter Hegyi, Zsuzsanna Polgár, Csaba Hegedűs, László Virág
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Biomedicines
Subjects:
acute pancreatitis
8-oxoguanine glycosylase
inflammation
cell death
necrosis
oxidative stress
Online Access:https://www.mdpi.com/2227-9059/10/10/2543

Internet

https://www.mdpi.com/2227-9059/10/10/2543

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