Ouabain exacerbates activation-induced cell death in human peripheral blood lymphocytes

Ouabain exacerbates activation-induced cell death in human peripheral blood lymphocytes

Lymphocytes activated by mitogenic lectins display changes in transmembrane potential, an elevation in the cytoplasmic Ca2+ concentrations, proliferation and/or activation induced cell death. Low concentrations of ouabain (an inhibitor of Na+,K+-ATPase) suppress mitogen-induced proliferation and inc...

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Bibliographic Details
Main Authors: Mabel B. Esteves, Luis F. Marques-Santos, Ottília R. Affonso-Mitidieri, Vivian M. Rumjanek
Format: Article
Language:English
Published: Academia Brasileira de Ciências 2005-06-01
Series:Anais da Academia Brasileira de Ciências
Subjects:
linfócitos
ouabaína
PHA
apoptose
despolarização de membrana
lymphocytes
ouabain
apoptosis
membrane depolarization
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652005000200008

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652005000200008

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