Systematic analyses of the sequence conservation and ligand interaction patterns of purinergic P1 and P2Y receptors provide a structural basis for receptor selectivity

Systematic analyses of the sequence conservation and ligand interaction patterns of purinergic P1 and P2Y receptors provide a structural basis for receptor selectivity

Purinergic receptors are membrane proteins that regulate numerous cellular functions by catalyzing reactions involving purine nucleotides or nucleosides. Among the three receptor families, i.e., P1, P2X, and P2Y, the P1 and P2Y receptors share common structural features of class A GPCR. Comprehensiv...

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Bibliographic Details
Main Authors: Ri Han, Hongryul Yoon, Jiho Yoo, Yoonji Lee
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Purinergic P1 and P2Y receptor
Sequence conservation
3D structures
Clustering
Receptor-ligand interactions
Ligand selectivity
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037023000120

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http://www.sciencedirect.com/science/article/pii/S2001037023000120

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