Vinculin and metavinculin exhibit distinct effects on focal adhesion properties, cell migration, and mechanotransduction.

Vinculin and metavinculin exhibit distinct effects on focal adhesion properties, cell migration, and mechanotransduction.

Vinculin (Vcn) is a ubiquitously expressed cytoskeletal protein that links transmembrane receptors to actin filaments, and plays a key role in regulating cell adhesion, motility, and force transmission. Metavinculin (MVcn) is a Vcn splice isoform that contains an additional exon encoding a 68-residu...

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Bibliographic Details
Main Authors: Hyunna T Lee, Lisa Sharek, E Timothy O'Brien, Fabio L Urbina, Stephanie L Gupton, Richard Superfine, Keith Burridge, Sharon L Campbell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0221962

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https://doi.org/10.1371/journal.pone.0221962

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