The subdued post-boost spike-directed secondary IgG antibody response in Ugandan recipients of the Pfizer-BioNTech BNT162b2 vaccine has implications for local vaccination policies

The subdued post-boost spike-directed secondary IgG antibody response in Ugandan recipients of the Pfizer-BioNTech BNT162b2 vaccine has implications for local vaccination policies

IntroductionThis study aimed to delineate longitudinal antibody responses to the Pfizer-BioNTech BNT162b2 COVID-19 vaccine within the Ugandan subset of the Sub-Saharan African (SSA) demographic, filling a significant gap in global datasets.MethodsWe enrolled 48 participants and collected 320 specime...

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Bibliographic Details
Main Authors: Violet Ankunda, Joseph Ssebwana Katende, Gerald Kevin Oluka, Jackson Sembera, Claire Baine, Geoffrey Odoch, Peter Ejou, Laban Kato, The COVID-19 Immunoprofiling Team, Pontiano Kaleebu, Jennifer Serwanga, Christine Hermilia Akoli, Angela Namuyanja, Solomon Opio, Arthur Watelo Kalyebi, Ivan Ssali, Ben Gombe, Susan Mugaba, Hellen Nantambi
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Immunology
Subjects:
Pfizer BioNTech BNT162b2 COVID-19 vaccine
longitudinal antibody responses
Sub-Saharan African populations
seropositivity classification
booster dose
breakthrough infections
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1325387/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1325387/full

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