APS8 Delays Tumor Growth in Mice by Inducing Apoptosis of Lung Adenocarcinoma Cells Expressing High Number of α7 Nicotinic Receptors

APS8 Delays Tumor Growth in Mice by Inducing Apoptosis of Lung Adenocarcinoma Cells Expressing High Number of α7 Nicotinic Receptors

The alkylpyridinium polymer APS8, a potent antagonist of α7 nicotinic acetylcholine receptors (nAChRs), selectively induces apoptosis in non-small cell lung cancer cells but not in normal lung fibroblasts. To explore the potential therapeutic value of APS8 for at least certain types of lun...

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Bibliographic Details
Main Authors: Sabina Berne, Maja Čemažar, Robert Frangež, Polona Juntes, Simona Kranjc, Marjana Grandič, Monika Savarin, Tom Turk
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Marine Drugs
Subjects:
lung cancer
antitumor activity
A549
HT29
CHRNA7
alkylpiridinium
SCID mice
toxicity
apoptosis
Online Access:http://www.mdpi.com/1660-3397/16/10/367

Internet

http://www.mdpi.com/1660-3397/16/10/367

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