Impaired replication stress response in cells from immunodeficiency patients carrying Cernunnos/XLF mutations.

Impaired replication stress response in cells from immunodeficiency patients carrying Cernunnos/XLF mutations.

Non-Homologous End Joining (NHEJ) is one of the two major pathways of DNA Double Strand Breaks (DSBs) repair. Mutations in human NHEJ genes can lead to immunodeficiency due to its role in V(D)J recombination in the immune system. In addition, most patients carrying mutations in NHEJ genes display de...

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Bibliographic Details
Main Authors: Michal Schwartz, Yifat S Oren, Assaf C Bester, Ayelet Rahat, Ruthy Sfez, Shlomo Yitzchaik, Jean-Pierre de Villartay, Batsheva Kerem
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2637976?pdf=render

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http://europepmc.org/articles/PMC2637976?pdf=render

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