ACE2 Co-evolutionary Pattern Suggests Targets for Pharmaceutical Intervention in the COVID-19 Pandemic

ACE2 Co-evolutionary Pattern Suggests Targets for Pharmaceutical Intervention in the COVID-19 Pandemic

Summary: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spillover infection in December 2019 has caused an unprecedented pandemic. SARS-CoV-2, as other coronaviruses, binds its target cells through the angiotensin-converting enzyme 2 (ACE2) receptor. Accordingly, this makes ACE2 re...

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Bibliographic Details
Main Authors: Maya Braun, Elad Sharon, Irene Unterman, Maya Miller, Anna Mellul Shtern, Shmuel Benenson, Alexander Vainstein, Yuval Tabach
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:iScience
Subjects:
Classification of Proteins
Evolutionary Mechanisms
Virology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220305721

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http://www.sciencedirect.com/science/article/pii/S2589004220305721

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