RB inactivation in keratin 18 positive thymic epithelial cells promotes non-cell autonomous T cell hyperproliferation in genetically engineered mice.

RB inactivation in keratin 18 positive thymic epithelial cells promotes non-cell autonomous T cell hyperproliferation in genetically engineered mice.

Thymic epithelial cells (TEC), as part of thymic stroma, provide essential growth factors/cytokines and self-antigens to support T cell development and selection. Deletion of Rb family proteins in adult thymic stroma leads to T cell hyperplasia in vivo. To determine whether deletion of Rb specifical...

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Bibliographic Details
Main Authors: Yurong Song, Teresa Sullivan, Kimberly Klarmann, Debra Gilbert, T Norene O'Sullivan, Lucy Lu, Sophie Wang, Diana C Haines, Terry Van Dyke, Jonathan R Keller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0171510&type=printable

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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0171510&type=printable

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