Effect of low oxygen conditions on matrix metalloproteinase-9 production of macrophages subjected to cyclic stretching: involvement of ERK and Rho kinase pathways

Effect of low oxygen conditions on matrix metalloproteinase-9 production of macrophages subjected to cyclic stretching: involvement of ERK and Rho kinase pathways

Macrophages infiltrated in the walls of abdominal aortic aneurysms (AAA) are subjected to cyclic stretching due to pulsatile deformation of blood vessels and low oxygen conditions caused by intraluminal thrombus. These conditions could induce aberrant changes in macrophage functions and lead local w...

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Bibliographic Details
Main Authors: Naoya SAKAMOTO, Kiyomi SADAMOTO
Format: Article
Language:English
Published: The Japan Society of Mechanical Engineers 2017-02-01
Series:Journal of Biomechanical Science and Engineering
Subjects:
macrophage
cyclic stretching
hypoxia
abdominal aortic aneurysm
matrix metalloproteinase
Online Access:https://www.jstage.jst.go.jp/article/jbse/12/1/12_16-00590/_pdf/-char/en

Internet

https://www.jstage.jst.go.jp/article/jbse/12/1/12_16-00590/_pdf/-char/en

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