A general synthesis of azetidines by copper-catalysed photoinduced anti-Baldwin radical cyclization of ynamides

A general synthesis of azetidines by copper-catalysed photoinduced anti-Baldwin radical cyclization of ynamides

The construction of four-membered rings via a 4-exo-dig cyclization was originally theorized to be unfavourable and only recently shown in sparse examples. Here the authors present a photochemical, radical 4-exo-dig cyclization of ynamides to form azetidines, promoted by copper photoredox catalysis.

Bibliographic Details
Main Authors: Clément Jacob, Hajar Baguia, Amaury Dubart, Samuel Oger, Pierre Thilmany, Jérôme Beaudelot, Christopher Deldaele, Stefano Peruško, Yohann Landrain, Bastien Michelet, Samuel Neale, Eugénie Romero, Cécile Moucheron, Veronique Van Speybroeck, Cédric Theunissen, Gwilherm Evano
Format: Article
Language:English
Published: Nature Portfolio 2022-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-28098-x

Internet

https://doi.org/10.1038/s41467-022-28098-x

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