Formulation Characterization and Pharmacokinetic Evaluation of Amorphous Solid Dispersions of Dasatinib

Formulation Characterization and Pharmacokinetic Evaluation of Amorphous Solid Dispersions of Dasatinib

The aim of this study was to improve the physicochemical properties and oral bioavailability of dasatinib (DST) by the amorphous solid dispersion (ASD) approach using cellulose acetate butyrate (CAB) as a carrier. Various formulations of ASD (DST:CAB 1:1 to 1:5) were prepared by the solvent evaporat...

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Bibliographic Details
Main Authors: Sathish Dharani, Eman M. Mohamed, Tahir Khuroo, Ziyaur Rahman, Mansoor A. Khan
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Pharmaceutics
Subjects:
dasatinib
amorphous solid dispersion
dissolution
stability
oral bioavailability
Online Access:https://www.mdpi.com/1999-4923/14/11/2450

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https://www.mdpi.com/1999-4923/14/11/2450

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