Partial deletion of chromosome 8 β-defensin cluster confers sperm dysfunction and infertility in male mice.

Partial deletion of chromosome 8 β-defensin cluster confers sperm dysfunction and infertility in male mice.

β-defensin peptides are a family of antimicrobial peptides present at mucosal surfaces, with the main site of expression under normal conditions in the male reproductive tract. Although they kill microbes in vitro and interact with immune cells, the precise role of these genes in vivo remains uncert...

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Bibliographic Details
Main Authors: Yu S Zhou, Sheila Webb, Laura Lettice, Steve Tardif, Fiona Kilanowski, Christine Tyrrell, Heather Macpherson, Fiona Semple, Peter Tennant, Tina Baker, Alan Hart, Paul Devenney, Paul Perry, Tracey Davey, Perdita Barran, Chris L Barratt, Julia R Dorin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-10-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3812073?pdf=render

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http://europepmc.org/articles/PMC3812073?pdf=render

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