Silibinin ameliorates deoxycholic acid-induced pyroptosis in steatotic HepG2 cells by inhibiting NLRP3 inflammasome activation

Silibinin ameliorates deoxycholic acid-induced pyroptosis in steatotic HepG2 cells by inhibiting NLRP3 inflammasome activation

Nonalcoholic steatohepatitis (NASH) represents an inflammatory subtype of nonalcoholic fatty liver disease (NAFLD). The activation of the NOD-like receptor protein 3 (NLRP3) inflammasome triggers pyroptosis, thus propelling the progression from simple steatosis to NASH. Silibinin, a hepatoprotective...

Full description

Bibliographic Details
Main Authors: Meiqing Mai, Ya Wang, Mengliu Luo, Zhongxia Li, Di Wang, Yongdui Ruan, Honghui Guo
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Biochemistry and Biophysics Reports
Subjects:
Silibinin
Pyroptosis
NLRP3 inflammasome
Deoxycholic acid
Inflammation
Nonalcoholic steatohepatitis
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580823001267

Internet

http://www.sciencedirect.com/science/article/pii/S2405580823001267

Similar Items