Physiological function of polyploid hepatocytes and pathological changes in its associated diseases
Liver is a unique organ with polyploidy. About 20 to 50 percent of hepatocytes in adult human are polyploid cells, which contain more than two sets of chromosomes. Hepatocytes polyploidization is triggered by the changes in insulin signal during weaning, and regulated by various cell cycle regulator...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Surgery Concepts & Practice
2023-11-01
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| Series: | Waike lilun yu shijian |
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| Online Access: | https://www.qk.sjtu.edu.cn/jscp/fileup/1007-9610/PDF/1709530094042-2010220622.pdf |
| _version_ | 1827330675151208448 |
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| author | ZHANG Yifan, LU Yiquan, HAO Fengjie, WANG Junqing |
| author_facet | ZHANG Yifan, LU Yiquan, HAO Fengjie, WANG Junqing |
| author_sort | ZHANG Yifan, LU Yiquan, HAO Fengjie, WANG Junqing |
| collection | DOAJ |
| description | Liver is a unique organ with polyploidy. About 20 to 50 percent of hepatocytes in adult human are polyploid cells, which contain more than two sets of chromosomes. Hepatocytes polyploidization is triggered by the changes in insulin signal during weaning, and regulated by various cell cycle regulator genes to ensure the polyploid cells proportion, ploidy and zonation. The regulation of polyploid hepatocytes is crucial for liver's metabolic and regenerative function, and protecting liver from tumorigenesis. However, in chronic virus hepatitis and nonalcoholic fatty liver disease, the pathological hepatocytes polyploidization can be found in disease progression because of cell cycle checkpoint inhibition and oxidative stress. Distinguishing physiological and pathological hepatocyte polyploidization will be helpful for the understanding the relationship between chronic liver disease and tumorigenesis. |
| first_indexed | 2024-03-07T16:17:55Z |
| format | Article |
| id | doaj.art-74aa09b8c4bd441593cae54a63588283 |
| institution | Directory Open Access Journal |
| issn | 1007-9610 |
| language | zho |
| last_indexed | 2024-03-07T16:17:55Z |
| publishDate | 2023-11-01 |
| publisher | Editorial Office of Journal of Surgery Concepts & Practice |
| record_format | Article |
| series | Waike lilun yu shijian |
| spelling | doaj.art-74aa09b8c4bd441593cae54a635882832024-03-04T09:43:54ZzhoEditorial Office of Journal of Surgery Concepts & PracticeWaike lilun yu shijian1007-96102023-11-01280657457910.16139/j.1007-9610.2023.06.015Physiological function of polyploid hepatocytes and pathological changes in its associated diseasesZHANG Yifan, LU Yiquan, HAO Fengjie, WANG Junqing0Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025Liver is a unique organ with polyploidy. About 20 to 50 percent of hepatocytes in adult human are polyploid cells, which contain more than two sets of chromosomes. Hepatocytes polyploidization is triggered by the changes in insulin signal during weaning, and regulated by various cell cycle regulator genes to ensure the polyploid cells proportion, ploidy and zonation. The regulation of polyploid hepatocytes is crucial for liver's metabolic and regenerative function, and protecting liver from tumorigenesis. However, in chronic virus hepatitis and nonalcoholic fatty liver disease, the pathological hepatocytes polyploidization can be found in disease progression because of cell cycle checkpoint inhibition and oxidative stress. Distinguishing physiological and pathological hepatocyte polyploidization will be helpful for the understanding the relationship between chronic liver disease and tumorigenesis.https://www.qk.sjtu.edu.cn/jscp/fileup/1007-9610/PDF/1709530094042-2010220622.pdf|ploidy|polyploidy|chromosomal instability|hepatocyte|hepatocellular carcinoma |
| spellingShingle | ZHANG Yifan, LU Yiquan, HAO Fengjie, WANG Junqing Physiological function of polyploid hepatocytes and pathological changes in its associated diseases Waike lilun yu shijian |ploidy|polyploidy|chromosomal instability|hepatocyte|hepatocellular carcinoma |
| title | Physiological function of polyploid hepatocytes and pathological changes in its associated diseases |
| title_full | Physiological function of polyploid hepatocytes and pathological changes in its associated diseases |
| title_fullStr | Physiological function of polyploid hepatocytes and pathological changes in its associated diseases |
| title_full_unstemmed | Physiological function of polyploid hepatocytes and pathological changes in its associated diseases |
| title_short | Physiological function of polyploid hepatocytes and pathological changes in its associated diseases |
| title_sort | physiological function of polyploid hepatocytes and pathological changes in its associated diseases |
| topic | |ploidy|polyploidy|chromosomal instability|hepatocyte|hepatocellular carcinoma |
| url | https://www.qk.sjtu.edu.cn/jscp/fileup/1007-9610/PDF/1709530094042-2010220622.pdf |
| work_keys_str_mv | AT zhangyifanluyiquanhaofengjiewangjunqing physiologicalfunctionofpolyploidhepatocytesandpathologicalchangesinitsassociateddiseases |