Aberrant signaling of immune cells in Sjögren’s syndrome patient subgroups upon interferon stimulation

Aberrant signaling of immune cells in Sjögren’s syndrome patient subgroups upon interferon stimulation

BackgroundPrimary Sjögren’s syndrome (pSS) is a systemic autoimmune disease, characterized by mononuclear cell infiltrates in the salivary and lacrimal glands, leading to glandular atrophy and dryness. Patient heterogeneity and lack of knowledge regarding its pathogenesis makes pSS a difficult disea...

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Bibliographic Details
Main Authors: Irene Sarkar, Richard Davies, Anders K. Aarebrot, Silje M. Solberg, Aleksandra Petrovic, Anagha M. Joshi, Brith Bergum, Johan G. Brun, Daniel Hammenfors, Roland Jonsson, Silke Appel
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
mass cytometry (CyTOF)
autoantibodies
Sjögren’s syndrome
type I and type II interferons
phospho-signaling
patient stratification
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.854183/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.854183/full

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