BPR0C261, An Analogous of Microtubule Disrupting Agent D-24851 Enhances the Radiosensitivity of Human Non-Small Cell Lung Cancer Cells via p53-Dependent and p53-Independent Pathways

BPR0C261, An Analogous of Microtubule Disrupting Agent D-24851 Enhances the Radiosensitivity of Human Non-Small Cell Lung Cancer Cells via p53-Dependent and p53-Independent Pathways

(1) Destabilization of microtubule dynamics is a primary strategy to inhibit fast growing tumor cells. The low cytotoxic derivative of microtubule inhibitor D-24851, named BPR0C261 exhibits antitumor activity via oral administration. In this study, we investigated if BPR0C261 could modulate the radi...

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Bibliographic Details
Main Authors: Jyh-Der Leu, Shih-Ting Lin, Chiung-Tong Chen, C.-Allen Chang, Yi-Jang Lee
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
NSCLC
BPR0C261
radiosensitivity
DNA damage
microtubule inhibitor
p53
Online Access:https://www.mdpi.com/1422-0067/23/22/14083

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https://www.mdpi.com/1422-0067/23/22/14083

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