Evidence for a Strong Relationship between the Cytotoxicity and Intracellular Location of β-Amyloid

Evidence for a Strong Relationship between the Cytotoxicity and Intracellular Location of β-Amyloid

β-Amyloid (Aβ) is a hallmark peptide of Alzheimer’s disease (AD). Herein, we explored the mechanism underlying the cytotoxicity of this peptide. Double treatment with oligomeric 42-amino-acid Aβ (Aβ42) species, which are more cytotoxic than other conformers such as monomers and fibrils, resulted in...

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Bibliographic Details
Main Authors: Md. Aminul Haque, Md. Selim Hossain, Tahmina Bilkis, Md. Imamul Islam, Il-Seon Park
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Life
Subjects:
β-amyloid
Alzheimer’s disease
cytotoxicity
cell permeability
oligomeric species
tAβ42
Online Access:https://www.mdpi.com/2075-1729/12/4/577

Internet

https://www.mdpi.com/2075-1729/12/4/577

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