Modulation of p53 activity by IκBα: Evidence suggesting a common phylogeny between NF-κB and p53 transcription factors

<p>Abstract</p> <p>Background</p> <p>In this work we present evidence that the p53 tumor suppressor protein and NF-κB transcription factors could be related through common descent from a family of ancestral transcription factors regulating cellular proliferation and apo...

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Bibliographic Details
Main Authors: Gelfand Erwin W, Nagasawa Masayuki, Dreyfus David H, Ghoda Lucy Y
Format: Article
Language:English
Published: BMC 2005-06-01
Series:BMC Immunology
Online Access:http://www.biomedcentral.com/1471-2172/6/12