Aberrant BUB1 Overexpression Promotes Mitotic Segregation Errors and Chromosomal Instability in Multiple Myeloma

Aberrant BUB1 Overexpression Promotes Mitotic Segregation Errors and Chromosomal Instability in Multiple Myeloma

Chromosome instability (CIN), the hallmarks of cancer, reflects ongoing chromosomal changes caused by chromosome segregation errors and results in whole chromosomal or segmental aneuploidy. In multiple myeloma (MM), CIN contributes to the acquisition of tumor heterogeneity, and thereby, to disease p...

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Bibliographic Details
Main Authors: Yuto Fujibayashi, Reiko Isa, Daichi Nishiyama, Natsumi Sakamoto-Inada, Norichika Kawasumi, Junko Yamaguchi, Saeko Kuwahara-Ota, Yayoi Matsumura-Kimoto, Taku Tsukamoto, Yoshiaki Chinen, Yuji Shimura, Tsutomu Kobayashi, Shigeo Horiike, Masafumi Taniwaki, Hiroshi Handa, Junya Kuroda
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
multiple myeloma
BUB1
chromosome segregation error
chromosomal instability
clonogenicity
Online Access:https://www.mdpi.com/2072-6694/12/8/2206

Internet

https://www.mdpi.com/2072-6694/12/8/2206

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