SpSrtA-Catalyzed Isopeptide Ligation on Lysine Residues

Sortase-mediated ligation (SML) is widely used for protein bioconjugation. However, the sortase used in this strategy typically recognizes only the N-terminal oligoglycine, which is absent in most natural proteins. To broaden the spectrum of substrates compatible with SML, we focus on a novel sortas...

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Bibliographic Details
Main Authors: Jiajia Wu, Tianyu Chu, Jian Hao, Liang Lin
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Microorganisms
Subjects:
Online Access:https://www.mdpi.com/2076-2607/12/1/179