Immunological and tumor-intrinsic mechanisms mediate the synergistic growth suppression of experimental glioblastoma by radiotherapy and MET inhibition

Immunological and tumor-intrinsic mechanisms mediate the synergistic growth suppression of experimental glioblastoma by radiotherapy and MET inhibition

Abstract The hepatocyte growth factor (HGF)/MET signaling pathway has been proposed to be involved in the resistance to radiotherapy of glioblastoma via proinvasive and DNA damage response pathways. Here we assessed the role of the MET pathway in the response to radiotherapy in vitro and in vivo in...

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Bibliographic Details
Main Authors: Manuela Silginer, Eleanna Papa, Emese Szabó, Flavio Vasella, Martin Pruschy, Christopher Stroh, Patrick Roth, Tobias Weiss, Michael Weller
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Acta Neuropathologica Communications
Subjects:
Glioma
HGF
Immunotherapy
Irradiation
Synergy
Online Access:https://doi.org/10.1186/s40478-023-01527-8

Internet

https://doi.org/10.1186/s40478-023-01527-8

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