Enhancer and Transcription Factor Dynamics during Myeloid Differentiation Reveal an Early Differentiation Block in Cebpa null Progenitors

Enhancer and Transcription Factor Dynamics during Myeloid Differentiation Reveal an Early Differentiation Block in Cebpa null Progenitors

Transcription factors PU.1 and CEBPA are required for the proper coordination of enhancer activity during granulocytic-monocytic (GM) lineage differentiation to form myeloid cells. However, precisely how these factors control the chronology of enhancer establishment during differentiation is not kno...

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Bibliographic Details
Main Authors: Sachin Pundhir, Felicia Kathrine Bratt Lauridsen, Mikkel Bruhn Schuster, Janus Schou Jakobsen, Ying Ge, Erwin Marten Schoof, Nicolas Rapin, Johannes Waage, Marie Sigurd Hasemann, Bo Torben Porse
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Cell Reports
Subjects:
PU.1
CEBPA
myelopoiesis
enhancer dynamics
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718307459

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http://www.sciencedirect.com/science/article/pii/S2211124718307459

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