Roles of Reactive Oxygen Species and Autophagy in the Pathogenesis of Cisplatin-Induced Acute Kidney Injury
Cisplatin-induced acute kidney injury (AKI) is the main factor restraining the clinical application of cisplatin. The AKI is associated with high mortality and morbidity, but no effective pharmacological treatment is available at present. As increased levels of reactive oxygen species (ROS) may prom...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Oxygen |
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| Online Access: | https://www.mdpi.com/2673-9801/2/3/22 |
| _version_ | 1797464294223249408 |
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| author | Sayuri Yoshikawa Kurumi Taniguchi Haruka Sawamura Yuka Ikeda Ai Tsuji Satoru Matsuda |
| author_facet | Sayuri Yoshikawa Kurumi Taniguchi Haruka Sawamura Yuka Ikeda Ai Tsuji Satoru Matsuda |
| author_sort | Sayuri Yoshikawa |
| collection | DOAJ |
| description | Cisplatin-induced acute kidney injury (AKI) is the main factor restraining the clinical application of cisplatin. The AKI is associated with high mortality and morbidity, but no effective pharmacological treatment is available at present. As increased levels of reactive oxygen species (ROS) may promote the progression of the injury, the elimination of ROS has been considered as an effective method to prevent the cisplatin-induced AKI. In addition, it has been revealed that an inducer of autophagy could protect kidney cells in the autophagy dependent manner. Induction of autophagy could also modulate the production of ROS in cases of renal injury. Therefore, kidney-targeted antioxidants and/or autophagy are urgently required for the better treatment of AKI. Accumulating evidence has indicated the important roles of gut microbiota in the pathogenesis of AKI. In addition, there is a scientific basis for considering future clinical applications of probiotics and/or prebiotics to treat cisplatin-induced AKI. Thus, gut microbiota might be a promising therapeutic target via the alteration of autophagy for the cancer therapy-induced nephrotoxicity. |
| first_indexed | 2024-03-09T18:05:14Z |
| format | Article |
| id | doaj.art-74d21eaa3dd949c2828edf1373e443ff |
| institution | Directory Open Access Journal |
| issn | 2673-9801 |
| language | English |
| last_indexed | 2024-03-09T18:05:14Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Oxygen |
| spelling | doaj.art-74d21eaa3dd949c2828edf1373e443ff2023-11-24T09:33:45ZengMDPI AGOxygen2673-98012022-08-012331732610.3390/oxygen2030022Roles of Reactive Oxygen Species and Autophagy in the Pathogenesis of Cisplatin-Induced Acute Kidney InjurySayuri Yoshikawa0Kurumi Taniguchi1Haruka Sawamura2Yuka Ikeda3Ai Tsuji4Satoru Matsuda5Department of Food Science and Nutrition, Nara Women’s University, Kita-Uoya Nishimachi, Nara 630-8506, JapanDepartment of Food Science and Nutrition, Nara Women’s University, Kita-Uoya Nishimachi, Nara 630-8506, JapanDepartment of Food Science and Nutrition, Nara Women’s University, Kita-Uoya Nishimachi, Nara 630-8506, JapanDepartment of Food Science and Nutrition, Nara Women’s University, Kita-Uoya Nishimachi, Nara 630-8506, JapanDepartment of Food Science and Nutrition, Nara Women’s University, Kita-Uoya Nishimachi, Nara 630-8506, JapanDepartment of Food Science and Nutrition, Nara Women’s University, Kita-Uoya Nishimachi, Nara 630-8506, JapanCisplatin-induced acute kidney injury (AKI) is the main factor restraining the clinical application of cisplatin. The AKI is associated with high mortality and morbidity, but no effective pharmacological treatment is available at present. As increased levels of reactive oxygen species (ROS) may promote the progression of the injury, the elimination of ROS has been considered as an effective method to prevent the cisplatin-induced AKI. In addition, it has been revealed that an inducer of autophagy could protect kidney cells in the autophagy dependent manner. Induction of autophagy could also modulate the production of ROS in cases of renal injury. Therefore, kidney-targeted antioxidants and/or autophagy are urgently required for the better treatment of AKI. Accumulating evidence has indicated the important roles of gut microbiota in the pathogenesis of AKI. In addition, there is a scientific basis for considering future clinical applications of probiotics and/or prebiotics to treat cisplatin-induced AKI. Thus, gut microbiota might be a promising therapeutic target via the alteration of autophagy for the cancer therapy-induced nephrotoxicity.https://www.mdpi.com/2673-9801/2/3/22cisplatinreactive oxygen speciesautophagyhistone deacetylasescanceracute kidney injury |
| spellingShingle | Sayuri Yoshikawa Kurumi Taniguchi Haruka Sawamura Yuka Ikeda Ai Tsuji Satoru Matsuda Roles of Reactive Oxygen Species and Autophagy in the Pathogenesis of Cisplatin-Induced Acute Kidney Injury Oxygen cisplatin reactive oxygen species autophagy histone deacetylases cancer acute kidney injury |
| title | Roles of Reactive Oxygen Species and Autophagy in the Pathogenesis of Cisplatin-Induced Acute Kidney Injury |
| title_full | Roles of Reactive Oxygen Species and Autophagy in the Pathogenesis of Cisplatin-Induced Acute Kidney Injury |
| title_fullStr | Roles of Reactive Oxygen Species and Autophagy in the Pathogenesis of Cisplatin-Induced Acute Kidney Injury |
| title_full_unstemmed | Roles of Reactive Oxygen Species and Autophagy in the Pathogenesis of Cisplatin-Induced Acute Kidney Injury |
| title_short | Roles of Reactive Oxygen Species and Autophagy in the Pathogenesis of Cisplatin-Induced Acute Kidney Injury |
| title_sort | roles of reactive oxygen species and autophagy in the pathogenesis of cisplatin induced acute kidney injury |
| topic | cisplatin reactive oxygen species autophagy histone deacetylases cancer acute kidney injury |
| url | https://www.mdpi.com/2673-9801/2/3/22 |
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