Dysregulation of Immune Response Mediators and Pain-Related Ion Channels Is Associated with Pain-like Behavior in the GLA KO Mouse Model of Fabry Disease

Dysregulation of Immune Response Mediators and Pain-Related Ion Channels Is Associated with Pain-like Behavior in the GLA KO Mouse Model of Fabry Disease

Fabry disease (FD) is a rare life-threatening disorder caused by deficiency of the alpha-galactosidase A (GLA) enzyme with a characteristic pain phenotype. Impaired GLA production or function leads to the accumulation of the cell membrane compound globotriaosylceramide (Gb3) in the neurons of the do...

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Bibliographic Details
Main Authors: Marlene Spitzel, Elise Wagner, Maximilian Breyer, Dorothea Henniger, Mehtap Bayin, Lukas Hofmann, Daniela Mauceri, Claudia Sommer, Nurcan Üçeyler
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cells
Subjects:
Fabry disease
globotriaosylceramide
inflammation
macrophages
cytokines
ion channels
Online Access:https://www.mdpi.com/2073-4409/11/11/1730

Internet

https://www.mdpi.com/2073-4409/11/11/1730

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