Ursodeoxycholic acid to reduce adverse perinatal outcomes for intrahepatic cholestasis of pregnancy: the PITCHES RCT

Ursodeoxycholic acid to reduce adverse perinatal outcomes for intrahepatic cholestasis of pregnancy: the PITCHES RCT

Background: Intrahepatic cholestasis of pregnancy, characterised by maternal pruritus and raised serum bile acid concentrations, is associated with increased rates of stillbirth, preterm birth and neonatal unit admission. Ursodeoxycholic acid is widely used as a treatment, but without an adequate ev...

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Bibliographic Details
Main Authors: Lucy C Chappell, Jennifer L Bell, Anne Smith, Catherine Rounding, Ursula Bowler, Louise Linsell, Edmund Juszczak, Sue Tohill, Amanda Redford, Peter H Dixon, Jenny Chambers, Rachael Hunter, Jon Dorling, Catherine Williamson, Jim G Thornton
Format: Article
Language:English
Published: NIHR Journals Library 2020-12-01
Series:Efficacy and Mechanism Evaluation
Subjects:
pregnancy
infant
newborn
humans
female
intrahepatic cholestasis of pregnancy
ursodeoxycholic acid
perinatal death
Online Access:https://doi.org/10.3310/eme07090

Internet

https://doi.org/10.3310/eme07090

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