Metabolic management of microenvironment acidity in glioblastoma

Metabolic management of microenvironment acidity in glioblastoma

Glioblastoma (GBM), similar to most cancers, is dependent on fermentation metabolism for the synthesis of biomass and energy (ATP) regardless of the cellular or genetic heterogeneity seen within the tumor. The transition from respiration to fermentation arises from the documented defects in the numb...

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Bibliographic Details
Main Authors: Thomas N. Seyfried, Gabriel Arismendi-Morillo, Giulio Zuccoli, Derek C. Lee, Tomas Duraj, Ahmed M. Elsakka, Joseph C. Maroon, Purna Mukherjee, Linh Ta, Laura Shelton, Dominic D'Agostino, Michael Kiebish, Christos Chinopoulos
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Oncology
Subjects:
glutaminolysis
glycolysis
fermentation
succinate
lactate
glutamate
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.968351/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.968351/full

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