Targeting pediatric cancers via T-cell recognition of the monomorphic MHC class I-related protein MR1

Targeting pediatric cancers via T-cell recognition of the monomorphic MHC class I-related protein MR1

Human leukocyte antigen (HLA) restriction of conventional T-cell targeting introduces complexity in generating T-cell therapy strategies for patients with cancer with diverse HLA-backgrounds. A subpopulation of atypical, major histocompatibility complex-I related protein 1 (MR1)-restricted T-cells,...

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Bibliographic Details
Main Authors: Aimee du Chatinier, Zsolt Sebestyen, Jürgen Kuball, Stefan Nierkens, Anja Krippner-Heidenreich, Yuyan Lu, Ana P Lopes, Ester Dunnebach, Denise A M H van den Beemt, Sebastiaan van Heesch, Annelisa M. Cornel, Loutje van der Sman, Jip T van Dinter, Marta Arrabito, Marliek van Hoesel, Thomas A Kluiver, Noël M M Dautzenberg, Linde Dekker, Jorik M van Rijn, Juliane L Buhl, Farnaz Barneh, Luca Lo Nigro, Esther Hulleman, Jarno Drost, Olaf T Heidenreich, Weng Chuan Peng
Format: Article
Language:English
Published: BMJ Publishing Group 2024-03-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/12/3/e007538.full

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https://jitc.bmj.com/content/12/3/e007538.full

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