Modeling Colorectal Cancer Progression Reveals Niche-Dependent Clonal Selection

Modeling Colorectal Cancer Progression Reveals Niche-Dependent Clonal Selection

Colorectal cancer (CRC) is among the deadliest cancers worldwide, with metastasis being the main cause of patient mortality. During CRC progression the complex tumor ecosystem changes in its composition at virtually every stage. However, clonal dynamics and associated niche-dependencies at these sta...

Full description

Bibliographic Details
Main Authors: Nuria Vaquero-Siguero, Nikolai Schleussner, Julia Volk, Manuel Mastel, Jasmin Meier, Rene Jackstadt
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cancers
Subjects:
colorectal cancer
metastasis
mouse models
mouse-derived organoids
orthotopic transplantation
tumor heterogeneity
Online Access:https://www.mdpi.com/2072-6694/14/17/4260

Internet

https://www.mdpi.com/2072-6694/14/17/4260

Similar Items