New insights into nucleic acid sensor AIM2: The potential benefit in targeted therapy for cancer

The AIM2 inflammasome represents a multifaceted oligomeric protein complex within the innate immune system, with the capacity to perceive double-stranded DNA (dsDNA) and engage in diverse physiological reactions and disease contexts, including cancer. While originally conceived as a discerning DNA s...

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Bibliographic Details
Main Authors: Jian-Zhou Cui, Zhi Huan Chew, Lina H.K. Lim
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Pharmacological Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661824000239