Deletion of rifampicin-inactivating mono-ADP-ribosyl transferase gene of Mycobacterium smegmatis globally altered gene expression profile that favoured increase in ROS levels and thereby antibiotic resister generation

Deletion of rifampicin-inactivating mono-ADP-ribosyl transferase gene of Mycobacterium smegmatis globally altered gene expression profile that favoured increase in ROS levels and thereby antibiotic resister generation

The physiological role of mono-ADP-ribosyl transferase (Arr) of Mycobacterium smegmatis, which inactivates rifampicin, remains unclear. An earlier study reported increased expression of arr during oxidative stress and DNA damage. This suggested a role for Arr in the oxidative status of the cell and...

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Bibliographic Details
Main Authors: Sharmada Swaminath, Atul Pradhan, Rashmi Ravindran Nair, Parthasarathi Ajitkumar
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Current Research in Microbial Sciences
Subjects:
Mycobacterium smegmatis
Mono-ADP-ribosyl transferase
Rifampicin
Reactive oxygen species
Mutation
Rifampicin resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2666517422000396

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http://www.sciencedirect.com/science/article/pii/S2666517422000396

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