27-Hydroxycholesterol-Induced Dysregulation of Cholesterol Metabolism Impairs Learning and Memory Ability in ApoE ε4 Transgenic Mice

27-Hydroxycholesterol-Induced Dysregulation of Cholesterol Metabolism Impairs Learning and Memory Ability in ApoE ε4 Transgenic Mice

Dysregulated brain cholesterol metabolism is one of the characteristics of Alzheimer’s disease (AD). 27-Hydroxycholesterol (27-OHC) is a cholesterol metabolite that plays an essential role in regulating cholesterol metabolism and it is suggested that it contributes to AD-related cognitive deficits....

Full description

Bibliographic Details
Main Authors: Yushan Wang, Ling Hao, Tao Wang, Wen Liu, Lijing Wang, Mengwei Ju, Wenjing Feng, Rong Xiao
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
27-hydroxycholesterol
cholesterol metabolism
homeostasis
learning and memory impairment
transgenic mice
Online Access:https://www.mdpi.com/1422-0067/23/19/11639

Internet

https://www.mdpi.com/1422-0067/23/19/11639

Similar Items