Multimodal nanoparticle‐containing modified suberoylanilide hydroxamic acid polymer conjugates to mitigate immune dysfunction in severe inflammation

Multimodal nanoparticle‐containing modified suberoylanilide hydroxamic acid polymer conjugates to mitigate immune dysfunction in severe inflammation

Abstract Excessive immune activation and immunosuppression are opposing factors that contribute to the dysregulated innate and adaptive immune responses seen in severe inflammation and sepsis. Here, a novel analog of the histone deacetylase inhibitor (HDACi), suberoylanilide hydroxamic acid (SAHA‐OH...

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Bibliographic Details
Main Authors: Nhu Truong, Andrea L. Cottingham, Shruti Dharmaraj, Jacob R. Shaw, Jackline Joy Martin Lasola, Christopher C. Goodis, Steven Fletcher, Ryan M. Pearson
Format: Article
Language:English
Published: Wiley 2024-01-01
Series:Bioengineering & Translational Medicine
Subjects:
drug delivery
histone deacetylase inhibitor
inflammation
lipopolysaccharide‐induced endotoxemia
nanoparticle
sepsis
Online Access:https://doi.org/10.1002/btm2.10611

Internet

https://doi.org/10.1002/btm2.10611

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