α-Synuclein disrupts microglial autophagy through STAT1-dependent suppression of Ulk1 transcription

α-Synuclein disrupts microglial autophagy through STAT1-dependent suppression of Ulk1 transcription

Abstract Background Autophagy dysfunction in glial cells is implicated in the pathogenesis of Parkinson’s disease (PD). The previous study reported that α-synuclein (α-Syn) disrupted autophagy in cultured microglia. However, the mechanism of microglial autophagy dysregulation is poorly understood. M...

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Bibliographic Details
Main Authors: Chong-Shuang Pei, Xiao-Ou Hou, Zhen-Yuan Ma, Hai-Yue Tu, Hai-Chun Qian, Yang Li, Kai Li, Chun-Feng Liu, Liang Ouyang, Jun-Yi Liu, Li-Fang Hu
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
ULK1
STAT1
α-synuclein
Autophagy
Parkinson’s disease
Online Access:https://doi.org/10.1186/s12974-024-03268-4

Internet

https://doi.org/10.1186/s12974-024-03268-4

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