Therapeutic targeting of P2X4 receptor and mitochondrial metabolism in clear cell renal carcinoma models

Therapeutic targeting of P2X4 receptor and mitochondrial metabolism in clear cell renal carcinoma models

Abstract Background Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cancer. Large-scale metabolomic data have associated metabolic alterations with the pathogenesis and progression of renal carcinoma and have correlated mitochondrial activity with poor survival in a subse...

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Bibliographic Details
Main Authors: Christofer Rupert, Carmela Dell’ Aversana, Laura Mosca, Vittorino Montanaro, Davide Arcaniolo, Marco De Sio, Antonio Bilancio, Lucia Altucci, Wulf Palinski, Roberto Pili, Filomena de Nigris
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Organoids
Mitochondria
Renal carcinoma
Lysosomes
Purinergic receptors
Drug screening
Online Access:https://doi.org/10.1186/s13046-023-02713-1

Internet

https://doi.org/10.1186/s13046-023-02713-1

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