SMYD5 catalyzes histone H3 lysine 36 trimethylation at promoters

SETD2 methylates histone H3K36me3 in gene bodies in mammalian cells. Here the authors show H3K36me3 is also enriched at the promoter regions, and that this methylation is carried out by SMYD5, which is recruited by RNA polymerase II. They furthermore show SMYD5 is elevated in liver cancer and is cor...

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Detalhes bibliográficos
Main Authors: Yanjun Zhang, Yuan Fang, Yin Tang, Shixun Han, Junqi Jia, Xinyi Wan, Jiaqi Chen, Ying Yuan, Bin Zhao, Dong Fang
Formato: Artigo
Idioma:English
Publicado em: Nature Portfolio 2022-06-01
Colecção:Nature Communications
Acesso em linha:https://doi.org/10.1038/s41467-022-30940-1