Smart antioxidant function enhancing (SAFE) nucleic acid therapy for ROS-related chronic diseases and comorbidities

Smart antioxidant function enhancing (SAFE) nucleic acid therapy for ROS-related chronic diseases and comorbidities

Reactive oxygen species (ROS)-mediated oxidative stress exacerbates chronic diseases such as organ damage and neurodegenerative disorders. The Keap1-Nrf2-ARE pathway is a widely distributed endogenous antioxidant system. However, ROS under redox homeostasis regulates a wide range of life activities....

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Bibliographic Details
Main Authors: Zhiguo Lu, Ruichen Zhao, Yi Li, Jianze Wang, Jing Guo, Chaobo Bai, Jing Chen, Jun Yang, Yiwan Geng, Tianlu Zhang, Yanyue Wu, Xiyue Jiao, Yining Wang, Junliang Yuan, Xin Zhang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-01-01
Series:Bioactive Materials
Subjects:
Smart antioxidant function enhancing (SAFE) strategy
Reactive oxygen species
Nucleic acid drugs
Keap1-Nrf2-ARE pathway
ROS-Associated chronic diseases and comorbidities
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X2300275X

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http://www.sciencedirect.com/science/article/pii/S2452199X2300275X

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