Shear Stress and the AMP-Activated Protein Kinase Independently Protect the Vascular Endothelium from Palmitate Lipotoxicity

Shear Stress and the AMP-Activated Protein Kinase Independently Protect the Vascular Endothelium from Palmitate Lipotoxicity

Saturated free fatty acids are thought to play a critical role in metabolic disorders associated with obesity, insulin resistance, type 2 diabetes (T2D), and their vascular complications via effects on the vascular endothelium. The most abundant saturated free fatty acid, palmitate, exerts lipotoxic...

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Bibliographic Details
Main Authors: Asker Y. Khapchaev, Alexander V. Vorotnikov, Olga A. Antonova, Mikhail V. Samsonov, Ekaterina A. Shestakova, Igor A. Sklyanik, Alina O. Tomilova, Marina V. Shestakova, Vladimir P. Shirinsky
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Biomedicines
Subjects:
vascular endothelium
AMP-activated protein kinase
shear stress
lipotoxicity
free fatty acid
Online Access:https://www.mdpi.com/2227-9059/12/2/339

Internet

https://www.mdpi.com/2227-9059/12/2/339

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