Pancreatic islet protection at the expense of secretory function involves serine-linked mitochondrial one-carbon metabolism

Pancreatic islet protection at the expense of secretory function involves serine-linked mitochondrial one-carbon metabolism

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Summary: Type 2 diabetes is characterized by insulin hypersecretion followed by reduced glucose-stimulated insulin secretion (GSIS). Here we show that acute stimulation of pancreatic islets with the insulin secretagogue dextrorphan (DXO) or glibenclamide enhances GSIS, whereas chronic treatment with...

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Bibliographic Details
Main Authors: Angela Pelligra, Jessica Mrugala, Kerstin Griess, Philip Kirschner, Oliver Nortmann, Barbara Bartosinska, Andrea Köster, Natalia I. Krupenko, Dominik Gebel, Philipp Westhoff, Bodo Steckel, Daniel Eberhard, Diran Herebian, Bengt-Frederik Belgardt, Jürgen Schrader, Andreas P.M. Weber, Sergey A. Krupenko, Eckhard Lammert
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Cell Reports
Subjects:
CP: Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723006265

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http://www.sciencedirect.com/science/article/pii/S2211124723006265

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