Pancreatic islet protection at the expense of secretory function involves serine-linked mitochondrial one-carbon metabolism

Summary: Type 2 diabetes is characterized by insulin hypersecretion followed by reduced glucose-stimulated insulin secretion (GSIS). Here we show that acute stimulation of pancreatic islets with the insulin secretagogue dextrorphan (DXO) or glibenclamide enhances GSIS, whereas chronic treatment with...

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Bibliographic Details
Main Authors:	Angela Pelligra, Jessica Mrugala, Kerstin Griess, Philip Kirschner, Oliver Nortmann, Barbara Bartosinska, Andrea Köster, Natalia I. Krupenko, Dominik Gebel, Philipp Westhoff, Bodo Steckel, Daniel Eberhard, Diran Herebian, Bengt-Frederik Belgardt, Jürgen Schrader, Andreas P.M. Weber, Sergey A. Krupenko, Eckhard Lammert
Format:	Article
Language:	English
Published:	Elsevier 2023-06-01
Series:	Cell Reports
Subjects:	CP: Metabolism
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124723006265

Pancreatic islet protection at the expense of secretory function involves serine-linked mitochondrial one-carbon metabolism by Angela Pelligra, Jessica Mrugala, Kerstin Griess, Philip Kirschner, Oliver Nortmann, Barbara Bartosinska, Andrea Köster, Natalia I. Krupenko, Dominik Gebel, Philipp Westhoff, Bodo Steckel, Daniel Eberhard, Diran Herebian, Bengt-Frederik Belgardt, Jürgen Schrader, Andreas P.M. Weber, Sergey A. Krupenko, Eckhard Lammert

Published 2023-07-01

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Pancreatic islet protection at the expense of secretory function involves serine-linked mitochondrial one-carbon metabolism

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