Adjustable extracellular matrix rigidity tumor model for studying stiffness dependent pancreatic ductal adenocarcinomas progression and tumor immunosuppression
Abstract Pancreatic ductal adenocarcinomas (PDAC) is one of the stiffest malignancies with strong solid stresses. Increasing stiffness could alter cellular behavior and trigger internal signaling pathways and is strongly associated with a poor prognosis in PDAC. So far, there has been no report on o...
Main Authors: | Haoxiang Zhang, Jiaoshun Chen, Xiaoqing Hu, Jianwei Bai, Tao Yin |
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Format: | Article |
Language: | English |
Published: |
Wiley
2023-05-01
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Series: | Bioengineering & Translational Medicine |
Subjects: | |
Online Access: | https://doi.org/10.1002/btm2.10518 |
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