Evaluation of hepatic integrin αvβ3 expression in non-alcoholic steatohepatitis (NASH) model mouse by 18F-FPP-RGD2 PET

Evaluation of hepatic integrin αvβ3 expression in non-alcoholic steatohepatitis (NASH) model mouse by 18F-FPP-RGD2 PET

Abstract Background Activated hepatic stellate cells (HSCs), which express integrin αvβ3, are a major fibrogenic factor in NASH pathophysiology. 18F-labeled cyclic arginine-glycine-aspartic acid penta-peptide (18F-FPP-RGD2) has been used as a PET probe for tumors expressing integrin αvβ3. The aim of...

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Bibliographic Details
Main Authors: Takemi Rokugawa, Haruyo Konishi, Miwa Ito, Hitoshi Iimori, Ryohei Nagai, Eku Shimosegawa, Jun Hatazawa, Kohji Abe
Format: Article
Language:English
Published: SpringerOpen 2018-05-01
Series:EJNMMI Research
Subjects:
Non-alcoholic fatty liver disease
Non-alcoholic steatohepatitis
Fibrosis
Positron emission tomography
18F-FPP-RGD2
Modified methionine choline-deficient
Online Access:http://link.springer.com/article/10.1186/s13550-018-0394-4

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http://link.springer.com/article/10.1186/s13550-018-0394-4

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