Discovery of potent heat shock protein 90 (Hsp90) inhibitors: structure-based virtual screening, molecular dynamics simulation, and biological evaluation

Discovery of potent heat shock protein 90 (Hsp90) inhibitors: structure-based virtual screening, molecular dynamics simulation, and biological evaluation

AbstractHeat shock protein 90 (Hsp90) is considered an attractive therapeutic target for cancer treatment due to its high expression in many cancers. In this study, four potent Hsp90 inhibitors (HPs 1–4) were identified using structure-based virtual screening. Among them, HP-4 exhibited the most pot...

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Bibliographic Details
Main Authors: Yonghua Xu, Yunting Zou, Shasha Zhou, Miao-Miao Niu, Yan Zhang, Jindong Li, Zhen Xu, Li Yang
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Hsp90
inhibitor
virtual screening
colon cancer
biological evaluation
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2023.2220558

Internet

https://www.tandfonline.com/doi/10.1080/14756366.2023.2220558

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