TGF-β1 Reduces Neutrophil Adhesion and Prevents Acute Vaso-Occlusive Processes in Sickle Cell Disease Mice

TGF-β1 Reduces Neutrophil Adhesion and Prevents Acute Vaso-Occlusive Processes in Sickle Cell Disease Mice

Sickle cell disease (SCD) patients experience chronic inflammation and recurrent vaso-occlusive episodes during their entire lifetime. Inflammation in SCD occurs with the overexpression of several inflammatory mediators, including transforming growth factor beta-1 (TGF-β1), a major immune regulator....

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Bibliographic Details
Main Authors: Lidiane S. Torres, Hanan Chweih, Fernanda C. Z. Fabris, Erica M. F. Gotardo, Flávia C. Leonardo, Sara T. Olalla Saad, Fernando F. Costa, Nicola Conran
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cells
Subjects:
inflammation
vaso-occlusion
sickle cell anemia
neutrophils
vascular adhesion
Online Access:https://www.mdpi.com/2073-4409/11/7/1200

Internet

https://www.mdpi.com/2073-4409/11/7/1200

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