VAPB-mediated ER-targeting stabilizes IRS-1 signalosomes to regulate insulin/IGF signaling

VAPB-mediated ER-targeting stabilizes IRS-1 signalosomes to regulate insulin/IGF signaling

Abstract The scaffold protein IRS-1 is an essential node in insulin/IGF signaling. It has long been recognized that the stability of IRS-1 is dependent on its endomembrane targeting. However, how IRS-1 targets the intracellular membrane, and what type of intracellular membrane is actually targeted,...

Full description

Bibliographic Details
Main Authors: Xiu Kui Gao, Zu Kang Sheng, Ye Hong Lu, Yu Ting Sun, Xi Sheng Rao, Lin Jing Shi, Xiao Xia Cong, Xiao Chen, Hao Bo Wu, Man Huang, Qiang Zheng, Jian-sheng Guo, Liang Jun Jiang, Li Ling Zheng, Yi Ting Zhou
Format: Article
Language:English
Published: Nature Publishing Group 2023-08-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-023-00576-6

Internet

https://doi.org/10.1038/s41421-023-00576-6

Similar Items